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Genomic Science Program

Today, scientists have in hand the complete DNA sequences of genomes for many organisms—from microbes to plants to humans. The U.S. Department of Energy's Genomic Science program (formerly Genomics:GTL) uses microbial and plant genomic data, high-throughput analytical technologies, and modeling and simulation to develop a predictive understanding of biological systems behavior relevant to solving energy and environmental challenges including bioenergy production, environmental remediation, and climate stabilization. Learn More »
A photo of a scientist. Click to learn more about biofuels.


Alternative fuels from renewable cellulosic biomass are expected to significantly reduce U.S. dependence on imported oil while enhancing national energy security and decreasing the environmental impacts of energy use. Developing a cost-effective, commercial-scale cellulosic biofuel industry will require transformational biological research in feedstock development, biomass deconstruction, and fuel synthesis. Learn More »

Click to learn more about the knowledgebase.


Driven by the ever-increasing wealth of data resulting from new generations of genomics-based technologies, systems biology is demanding a computational environment for comparing and integrating large, heterogeneous datasets and using this information to develop predictive models. To address this challenge, the Genomic Science program is developing the DOE Systems Biology Knowledgebase. Learn More »

Click to learn more about carbon cycling and the climate.

Carbon Cycling and Climate

The global carbon cycle plays a central role in regulating atmospheric carbon dioxide levels and thus Earth’s climate, but our basic understanding of the tightly interlinked biological processes driving the carbon cycle remains limited. Advancing our knowledge of these processes is crucial to predicting potential climate change impacts, assessing the viability of climate change adaptation and mitigation strategies, and informing relevant policy decisions. Learn More »


Genomic Science Program 2014 Strategic Plan [10/14]

Systems Biology-Enabled Research for Microbial Production of Advanced Biofuels (Summary of Funded Projects) [9/14]

Plant Feedstock Genomics for Bioenergy Abstracts [07/14]

Sustainable Bioenergy [05/14]

Bioenergy Research Centers [02/14]




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Programmatic Contact:
Joseph Graber
U.S. Department of Energy (SC-72)
Office of Biological and Environmental Research