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Genomic Science Program

Systems Biology for Energy and the Environment

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Genomic Science Program

Genomes to Life Contractor-Grantee Workshop I
Arlington, Virginia, February 9-12, 2003

Workshop Breakout Session

Regulatory networks, including computational needs


  • Adam Arkin, Lawrence Berkeley National Laboratory
  • F. Robert Tabita, Ohio State University

The purpose of this breakout session is to address key needs and issues associated with the identification, characterization and analysis of bacterial regulatory networks in the Genomes to Life program. The session will include: a discussion of experimental design for network deduction, specific examples that illustrate the role of global regulation and cross-talk among pathways for determining cellular physiology, plus challenges that exist to functional genomic analysis and storage of network information. After a brief introduction to the particulars of cellular regulatory networks and what is meant by global regulation and cross talk, a panel will briefly discuss their views on the issues surrounding measurement and analysis of interactive pathways and stimulate discussion with the audience. In addition, we encourage you to bring one or two viewgraphs to share with the participants on your views about emerging capabilities or research needs for analyzing regulatory pathways, from their deduction, to their cross-species comparison, to their dynamic modeling.

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