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Systems Biology for Energy and the Environment

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Genomic Science Program

DOE Systems Biology Knowledgebase
Implementation Plan

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The DOE Systems Biology Knowledgebase Implementation Plan describes the tasks needed to provide the research community with a comprehensive cyberinfrastructure to advance systems biology research over the next several years. It articulates the scope and plans necessary to begin the Kbase effort and outlines a strategy for Kbase support of key research objectives in the microbial, plant, and metacommunity sciences. These objectives include metabolic reconstruction and modeling, inference of gene regulatory networks, linkage of phenotypic and experimental data and metadata, and assembly, integration, annotation, and mining of omics and other types of data. The implementation plan notes the need to leverage existing community resources and projects and describes the tasks, timelines, and plan for establishing Kbase’s underlying infrastructure. It also discusses additional project components such as architecture, governance, and project management.

Publication date: September 30, 2010

Suggested citation: U.S. DOE. 2010. DOE Systems Biology Knowledgebase Implementation Plan. U.S. Department of Energy Office of Science (

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