Genomic Science Program

Genomic Science Program Research Awards

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Analysis of the Genetic Potential and Gene Expression of Microbial Communities Involved in the in situ Bioremediation of Uranium and Harvesting Electrical Energy from Organic Matter

University of Massachusetts, Amherst
Derek Lovely, Principal Investigator
$8.9 million over 3 years
Funded: FY2002

Research Partners:

• The Institute for Genomic Research
  Barbara Methe, Co-Principal Investigator
• Argonne National Laboratory
  Carol Giometti, Co-Principal Investigator
• University of Tennessee, Memphis
  Julia Krushkal, Co-Principal Investigator

This team will study a family of microbes with the potential for uranium bioremediation and, remarkably, for production of electricity through their ability to transfer electrons to electrodes. The research's goal is to develop computational models that can predict the activity of communities of these microbes in their natural environment. This knowledge in turn can predict the success of bioremediation and energy production under different environmental conditions.

Website

Abstracts

• 2005 Contractor-Grantee Workshop
  • University of Massachusetts, Amherst (PDF, 216 kb)
  • Progress Toward Genome-Scale Monitoring of In Situ Gene Expression During Uranium Bioremediation and Electricity Harvesting
  • Integrating Phenotypic and Expression Data to Characterize Metabolism in G. sulfurreducens
  • Novel Regulatory Systems and Adaption of Some Well-Known Systems Controlling Respiration, Growth, and Chemotaxis of Geobactor Species
  • Nanowires, Capacitors, and Other Novel Electron Transfer Mechanisms in Geobacter Species Elucidated from Genome-Scale Investigations
  • Continued Progress in the use of Microarray Technology to Predict Gene Regulation and Function in Geobacter sulfurreducens
• 2004 Contractor-Grantee Workshop
  • Analysis of Predominant Genome Sequences and Gene Expression During In Situ Uranium Bioremediation and Harvesting Electricity from Waste Organic Matter
  • Functional Analysis of Genes Involved in Electron Transport to Metals in Geobacter sulfurreducens
  • Adapting Regulatory Strategies for Life in the Subsurface: Regulatory Systems in Geobacter sulfurreducens
• 2003 Contractor-Grantee Workshop
  • Analysis of the Genetic Potential and Gene Expression of Microbial Communities Involved in the in situ Bioremediation of Uranium and Harvesting Electrical Energy from Organic Matter