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2003 Genomics:GTL-Related U.S. Department of Energy Small Business Innovation Research (SBIR) Projects

Three winners of 2003 SBIR Phase II awards may help to speed scientific discovery in the Genomics:GTL Program

  • Model-Driven Strain Design for Pseudomonas fluorescens
    Genomatica, Inc.
    5405 Morehouse Drive, Suite 210
    San Diego, CA 92121-4722

    A computational technology will be developed to assemble a metabolic model based on genomic, biochemical, and physiological information that will predict cellular functions of organisms under changing physiological and genetic conditions. These predictive capabilities will enable the model to be useful in guiding future experimental research and process improvements.

  • Single-Cell Genomics of Hyperthermophiles
    Lucigen Corporation
    2120 W. Greenview Drive
    Middleton, WI 53562-2547

    This project will sequence the genome of a single microbial cell, resulting in a 500-fold increase in the genetic information known about bacteria. Such knowledge will enable advances in medicine and biotechnology, as well as economic and environmental advances for industrial processing and increased understanding of microbes in the environment.

  • DNA Amplification of the Whole Genome from a Single Cell
    Molecular Staging Incorporated
    300 George Street, 7th Floor
    New Haven, CT 06511-6652

    A method will be developed to accurately produce millions of DNA copies
    starting from a single bacterial cell, making it possible to sequence the genome of thousands of new bacterial species and accelerate research into microbiology, infectious diseases, and biological warfare.

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Genomic Science-Related BER Research Highlights

  • Protein Complex Within Plant Cell Wall Associated with Secondary Cell-Wall Synthesis [Nov 30, 2011]
    The plant cell wall polysaccharide pectin is often associated with the tissue softening that occu [more...]
  • Designing Low Lignin, High Biomass Yielding Plants [Nov 28, 2011]
    The major barrier to the efficient conversion of biomass from plant feedstocks to biofuels is bre [more...]
  • Microbial Conversion of Switchgrass to Multiple Drop-In Biofuels [Nov 28, 2011]
    The low efficiency and high cost of enzymes used to break down plant material into sugars remains [more...]
  • How do Microbes Adapt to Diverse Environments? [Nov 22, 2011]
    Earth's microbes live in staggeringly diverse environments, colonizing habitats with extremes of [more...]
  • Permafrost Microbes Could Make Impacts of Arctic Warming Worse [Nov 06, 2011]
    In Earth’s Arctic regions, frozen soils (permafrost) sequester an estimated 1.6 trillion metric t [more...]
  • More BER Research Highlights »