Genomic Science Program

Genomic Science Program Research Awards

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Microbial Ecology, Proteogenomics and Computational Optima

Harvard Medical School
George Church, Principal Investigator
$15 million over 5 years
Funded: FY2002

Research Partners:

• Massachusetts Institute of Technology
  Sallie Chisholm, Co-Principal Investigator
• Brigham and Women’s Hospital, Boston MA
  Raju Kucherlapati, Co-Principal Investigator
• Massachusetts General Hospital
  Frederick Ausubel, Co-Principal Investigator

This team will study two different microbes—one that plays a significant role in earth's carbon cycle, and another with broad metabolic diversity. The team will study the proteins and protein-protein interactions in these microbes, the gene regulatory networks that control the production of these proteins and the behavior of these microbes as complex environmental communities. They will develop computational methods to understand the biology of these microbes at a systems level.

Website

Abstracts

• 2005 Contractor-Grantee Workshop
  • Harvard Medical School (PDF, 142 kb)
  • Metabolic Network Modeling of Prochlorococcus marinus
  • Quantitative Proteomics of Prochlorococcus marinus
  • Genome Sequencing from Single Cells with Ploning
• 2004 Contractor-Grantee Workshop
  • Flux Balance Based Whole-Cell Modeling of the Marine Cyanobacterium Prochlorococcus
• 2003 Contractor-Grantee Workshop
  • Microbial Ecology, Proteogenomics, and Computational Optima

Proposal:

• Introduction
• Goal 1: Protein complexes & Mass Spectrometry
• Goal 2: Regulatory Networks and RNA quantitation.
• Goal 3: Microbial Communities, Tn tags, Single Cell Activity Multiplexing, and biofilms
• Goal 4: Computational models on the edge of optimality & 4D cell models
• Conclusion/Management/Bibliography

Proposal in MS-Word